Norman Lear’s work was an integral part of American life in the second half of the 20th Century. Television programs like Maude, Sanford and Son, and The Jeffersons dragged television out of the 1950s and into the real world. As Variety states: “Lear’s shows were the first to address the serious political, cultural and social flashpoints of the day – racism, abortion, feminism, homosexuality, the Vietnam war – by working pointed new wrinkles into the standard domestic comedy formula. No subject was taboo: Two 1977 episodes of All in the Family revolved around the attempted rape of lead character Archie Bunker’s wife Edith.”
All in the Family, which ran on CBS from 1971 to 1979, typified the clash of generations. Middle-aged bigot Archie Bunker – played by Carrol O’Connor – was a right-wing King Lear in Queens, raging at the radical changes in society. Archie didn’t let ignorance get in the way of his opinions; once he argued that people who lived in communes were communists. The thing is, the old dog was actually capable of learning new tricks. Archie never evolved into any kind of saint. But over the nine seasons "Family" aired, experience taught Archie the benefits of listening to (and respecting) viewpoints far different from his own.
All in the Family was the jewel in Lear’s crown, but don’t forget the highly popular shows One Day at a Time (which featured Bonnie Franklin as a divorcee raising two daughters in the Midwest) and Mary Hartman, Mary Hartman (with Louise Lasser as the titular figure in a parody of soap opera conventions). Good or bad, Lear’s work was never indifferent.
More recently, you may have heard about Lear’s lively activism. His TV shows were themselves arguments for free and unfettered speech, and Lear supported a slate of liberal causes. In 1981 he founded People for the American Way. The organization’s website describes the ways that PFAW has “engaged cultural and community leaders and individual activists in campaigns promoting freedom of expression, civic engagement, fair courts, and legal and lived equality for LGBTQ people.”
Lear’s life was a long and fulfilling one. In 1978 he was given the first of two Peabody Awards, the most prestigious award in television. “To Norman Lear,” it reads, “...for giving us comedy with a social conscience. He uses humor to give us a better understanding of social issues. He lets us laugh at our own shortcomings and prejudices, and while doing this, maintains the highest entertainment standards.”
A pioneer, a gadfly of the state, a mensch. To paraphrase a lyric from All in the Family’s theme song, “Mister, we could use a guy like Norman Lear again.”
Is biohacking as scary as it's been made out to be?
Keoni Gandall, an 18-year-old research fellow at Stanford, has eschewed video games and team sports in favor of using advanced lab equipment to perform DIY gene editing. Using the widely available CRISPR/Cas9, Gandall wants to clone DNA and eventually make full genomes at home. The availability of this technology represents a new democratization of science, a science that can be performed anywhere by anyone relatively cheaply. That said, there's always a price associated with this type of freedom.
As barriers to entry to the scientific community are torn down, the world is exposed to the ideas and experiments of people outside of genetic science's traditional university setting. That said, more ideas don't necessarily mean better ideas. Biotech firm Ascendance Biomedical seemed committed to proving this point when their CEO Aaron Traywick injected himself with a DIY herpes medication in front of a crowd in Austin this February. This is the same company that urged Tristan Roberts to inject himself with an untested gene therapy to treat his HIV. Neither of these experiments worked, but they do paint an interesting picture of what we can expect in the future. Ease of access combined with relatively lax FDA standards about testing experimental medicines on oneself will eventually give rise to more companies like Ascendance Biomedical. Sure, this may present a sort of minor competition with Big Pharma with regard to curing certain diseases, but the danger of injecting oneself with a mystery cocktail created by someone with a few thousand dollars worth of gene-editing technology cannot be overstated.
Traywick injecting himself with his DIY herpes medication.
Still, incompetent gene editors like Traywick are a bigger danger to themselves than others. The real concern with the dissemination of this technology is the potential for it to be used in the manufacturing of homemade biochemical weapons. Recently, researchers at the University of Alberta were able to recreate Horsepox, an extinct relative of the smallpox virus. It only cost them $100,000, and it took about six months. While this price point will keep hobbyists like Gandall from reproducing extinct diseases, the lack of government oversight regarding the University's experiment is frightening. Genetic science is improving at a rate faster than legislation regulating DNA experimentation can be churned out. In the wrong hands, the dangers associated with viral editing are incalculable.
Back in 2016, researchers at MIT invented a programming language that allows them to design and edit DNA. Supposedly, anyone fluent in this language is able to generate and edit a DNA sequence from their computer. Before this language was invented, advanced gene editing required years of experience. According to scientists at MIT, now anyone with some programming skills can create, edit, and model DNA. According to MIT professor Christopher Voigt, "it is literally a programming language for bacteria." The medical applications are seemingly endless, but there are concerns regarding accessibility. If every person with a computer has the ability to design new genetic material, biological attacks won't just increase in number, their origins will also become more and more difficult to trace.
Analysis of DNA's nucleotides
While the growing anxiety surrounding biohacking is certainly warranted, there are plenty of professional geneticists out there who don't seem to be worried, and most of them don't believe that DNA sequencing is anything like a computer language. Synthetic biologist Sarah Richardson believes that this line of thinking has given bioengineers unrealistic expectations saying, "any analogy that ignores or downplays the fundamental rule of biology — that a cell makes imperfect copies of itself — is going to lead down a frustrating and unproductive path." According to her, we haven't even learned what some of our genes actually do, and that those worrying about the rise of biohacking are being tricked into fear. Scientists are quick to admonish the risky and often outright stupid Garageband biohackers out there, because as of right now, there's still a ton that our top geneticists don't know. We only finished mapping the human genome 15 years ago. Hell, it's only been 65 years since we discovered DNA. We're just not at the point where people with little-to-no real lab experience can accurately sequence and edit DNA from their basement. Still, the time is coming when this type of DIY genetic editing will be possible and accessible, which is why many in the bioethics community are arguing that t we need to start having the conversation now–while biohacking is in its infancy–so we can draw up preemptive legislation. One can only imagine the damage Aaron Traywick's could do if this technology were more advanced.